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Xianjun Dong, PhD

Xianjun Dong is an Assistant Professor in the Department of Neurology at Harvard Medical School, a Faculty member of the HMS Initiative for RNA Medicine, and an Associate Member of the Broad Institute. Since 2020, Dr. Dong has been appointed to direct this Genomics and Bioinformatics Hub at Brigham and Women’s Hospital (BWH) and also run his own research lab as an independent PI. Before taking this position, Dr. Dong has been serving as the Director of the Computational Neuroscience Unit of the Precision Neurology Program at BWH and an Instructor at Harvard Medical School for 7 years. He is specialised in developing and applying computational methods to understand the transcriptional regulation of the human genome, by integrating genomic, transcriptomic, epigenetic, and clinical data from both healthy subjects and patients with neurological diseases. He is particularly interested in the non-coding RNAs (eRNA, circRNA, miRNA, etc.) in the human brain. He has expertise in analyzing various NGS data, incl. ChIPseq, RNAseq, RNA-PET, CAGE, and WGS data.

Dr. Dong received his PhD degree in Bioinformatics at the University of Bergen (supervisor: Boris Lenhard) and a Postdoctoral fellowship in Bioinformatics and Integrative Biology at the University of Massachusetts Medical School (supervisor: Zhiping Weng). He was an active member of the ENCODE consortium. He has 40+ publications with 20,000+ citations and an H-index of 24. He is recently awarded by the American Parkinson’s Disease Association (APDA)Aligning Science Across Parkinson’s (ASAP), and NIH (R01, U01, R41, P19). In his spare time, he raises three kids and 15 chickens.

[Biosketch] | [Github] | [Pubmed]

Jie Yuan, PhD

Jie Yuan is currently a postdoctoral fellow in Dr. Dong’s lab at the Department of Neurology at BWH and Harvard Medical School, studying risk factors and biomarkers for Parkinson’s disease. Jie completed his PhD in computer science at Columbia University working on statistical tools for GWAS analysis, including methods to identify disease subtypes with unique SNP associations (Yuan et al. Nature Genetics, 2018; Yuan et al. PLoS Genetics, 2020). He is broadly interested in deep learning and other topics in machine learning and their applications to genomics and epigenetics. He is an avid (though amateur) chess player and puzzle solver in his free time.

Ruifeng Hu, PhD

Ruifeng Hu is currently a research fellow in Dr. Dong’s lab at the Department of Neurology at BWH and Harvard Medical School. Ruifeng received his Ph.D. degree in the Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC), China. Before joining Harvard, Ruifeng did his postdoctoral fellow at the University of Texas Health Science Center at Houston. His research is focused on but not limited to develop computational methods to unveil the hidden biological circuitries underlying the data, from understanding sequence-based regulations to the genomes or epigenomes and their impacts on diseases. Ruifeng is proficient in Python, C++, and C. He likes hiking/traveling/hand-writing/watching movies/reading in his spare time.

Daianna González

Daianna González is a Genomic Sciences undergraduate student at the National Autonomous University of Mexico (NAUM). She is currently a research student in the Hub. She is interested in applying bioinformatics to understand the underlying gene regulation mechanisms of brain disease through omics data analysis in order to ultimately design effective therapies and drugs. In 2019 Daianna won the first place in the National Carma Women’s Mathematics Olympiad.

Ziqin Wang

Ziqin is a graduated Master’s student who majored in Biostatistics at the University of California, Davis, and he got his Bachelor’s degree in Mathematics at the University of California, San Diego, During his study at both undergraduate and graduate school, he got proficient skills in Survival Analysis and constructing various kinds of statistical models on analyzing clinical data, also he got rich experience in coding with R. Currently he is a research assistant for the lab, with profound interests in analyzing genomics data. He is also a good Ping Pong player and Sudoku lover.

Rosan Wang

Rosan is a research student in the Hub. She is currently a third-year undergraduate student studying Biochemistry and Data Science at Northeastern University and has previously worked as a Bioinformatics Analyst at a small molecule RNA splicing startup company. Rosan is interested in studying omics data to better understand disease progression and gene expression in neurological diseases. In her spare time, she enjoys knitting and crocheting.

Ewa Grassin, PhD

Ewa is currently a Postdoctoral Research Fellow in Dr. Luke Lee’s group and jointly in Dr. Dong’s group at Brigham and Women’s Hospital and Harvard Medical School. Ewa is awarded the Swiss National Science Foundation Fellowship to investigate the role of extracellular vesicles in the development and progression of human brain disorders using patient-derived iPSC-based organoids on a novel multiplexed microfluidic platform. Ewa received her PhD in Chemistry at the University of Geneva, Switzerland, discovering the novel phenomenon of synergy between human antimicrobial peptides. In her spare time, she enjoys riding a motorcycle, scuba diving, and dancing classical ballet.

Qinyun Lin

Qinyun is a co-op student in the hub. He is currently a second-year master’s student in Computer Science at Northeastern University. Qinqyun is interested in and familiar with several technical fields including AI, Computer Vision, Point Cloud, SLAM and Software Engineering. Five years of experience in Computer Science help him to know the complexity and diversity of real-world problems and establish his interest in Bioinformatics now.

[Github] | [LinkedIn]

Miles Waits

Miles Waits

Miles is doing a remote, part-time internship in the hub. He graduated from Yale University in 2021 with a degree in physics and a data science certificate. Miles is interested in applying his data science skillsets to perform the pharmacome data in the PPMI study.

Matthew G. Torre, M.D.

Matthew G. Torre, MD

Matthew is an affiliated member of the hub and an Instructor in Pathology at Brigham and Women’s Hospital. He is interested in using bioinformatics to uncover novel mechanisms underlying chemotherapy-related cognitive impairment.

Xiaohe (Lucy) Tian

Lucy is a part-time student researcher in the lab. She is currently a first-year Master’s student in the Computational Biology and Quantitative Genetics program at Harvard T.H. Chan. Her major interest lies in employing machine learning and multi-dimensional data analysis to detect patterns across integrated omics data in chronic disease development. She graduated with honors from UC Berkeley in 2022 with a dual degree in Microbial Biology and Data Science. She enjoys both the outdoors and alone time at home watching anime.

Allison Mello

Allison is the Administrative Assistant for the Genomics and Bioinformatics Hub, providing support for all aspects of the hub mission. Prior to joining BWH, Ms. Mello Interned at the Massachusetts Commission Against Discrimination as an Administrative Support/Language Access Intern. Ms. Mello recently graduated with Academic Honors from Bay State College with a degree in Management alongside a concentration specifically in Healthcare Management. During her time at Bay State College, she was recognized with a Program Leadership Award.

Sherri Schwaninger, MBA

Sherri Schwaninger, MBA is Program Manager supporting the Scherzer/Dong/Lemere Labs. Sherri has been a healthcare manager for 35 years spending the first 17 years of her career with Partners’ Neurology at MGH and BWH, where she had responsibility for research finance and clinical operations. Shifting to the pharmaceutical industry, Sherri spent 16+ years as Head of Operations, Biologics and Imaging, at Novartis. Her focus was on lab operations and operating and capital budget management. Sherri has returned to the BWH after a short retirement. She earned her MBA from Simmons University and her Bachelor of Arts degree in English from UMASS Boston.

Alumini

  • Grace Reed, co-op student, 2021-2022
  • Tingting Zhao, PhD, research scientist, 2021-2022
  • Ariela Buxbaum Grice, research trainee, 2020-2021
  • Mrinal Subash, co-op student, 2019-2020
  • Xiaoqi “Ava” Li, research assistant, 2020-2021
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