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Transcriptional regulation

  • Discovery of regulatory elements (e.g. promoter, enhancer) in the vertebrate genome;
  • Epigenetic regulation of gene expression;
  • cis– and trans-regulation of genetic variants (both SNP and SV) to gene expression, e.g. eQTL, in both healthy control and disease setting

Non-coding RNAs and their role in disease

  • Identifying novel non-coding RNAs (e.g. miRNA, eRNA, piRNA, circRNA) in the human genome;
  • Expression profile of non-coding RNAs in the brain;
  • Function of non-coding RNAs in neurological disorders;

Applying AI to disease prediction

  • Integrationof multi-dimensional multi-source data (e.g. omics, clinical, imaging, and wearable device)
  • Applying the latest machine learning methods to predict diseaes prognosis, dianosis, and progression
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