Research

Transcriptional regulation

• Discovery of regulatory elements (e.g. promoter, enhancer) in the vertebrate genome;
• Epigenetic regulation of gene expression;
• cis– and trans-regulation of genetic variants (both SNP and SV) to gene expression, e.g. eQTL, in both healthy control and disease setting;

Non-coding RNAs and their role in disease

• Identifying novel non-coding RNAs (e.g. miRNA, eRNA, piRNA, circRNA) in the human genome;
• Expression profile of non-coding RNAs in the brain;
• Function of non-coding RNAs in neurological disorders;

Applying AI to disease prediction

• Integration of multi-dimensional multi-source data (e.g. omics, clinical, imaging, and wearable device);
• Applying the latest machine learning methods to predict disease diagnosis and progression.